As a handling editor, after a preliminary content check, you may either decide to send the manuscript out for review or recommend it for immediate rejection to the Specialty Chief Editor.
In the latter case, the Specialty Chief Editor may confirm the Associate Editor’s recommendation of immediate article rejection due to the following reasons:
An objective error (generally accepted by the community and not one that would be debatable by some)
An excessive number of language errors
Lack of research quality or ethical standards
The Specialty Chief Editor may, nevertheless, override the Associate Editor's recommendation and decide that the manuscript deserves being reviewed, in which case he/she will assign the article to a new Associate Editor who agrees to send the article for review [Review Guidelines].